Effects of 12 weeks yoga with vitamin D supplementation on the expression of NF-kB and p53 genes in lymphocyte on breast cancer survivors
Oral Presentation
Paper ID : 1524-12THCONG
Oral / Poster Presentation File: 12th Cong Presentation_1 11111.mp4
Authors
1MSc in Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran.
2Assistant Professor in Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran.
3Assistant Professor in Exercise Physiology, School of Nutrition and Dietetics, Acadia University, Wolfville, NS, Canada.
Abstract
Regular exercise training is the best non-pharmacological way to mitigate the side effects of cancer and its pharmacological treatment. Exercise training promotes the quality of life of breast cancer survivors. This study aimed to investigate the effects of a 12-week period yoga with consumption vitamin D supplementation on the expression of NF-kB and p53 genes of lymphocyte in breast cancer survivors.
Thirty female breast cancer survivors were randomized equally into three groups: high dose of vitamin D supplementation 4000 IU (HD), yoga with high dose of vitamin D 4000 IU (YHD), yoga with low dose of vitamin D 2000 IU(YLD). Experimental groups performed cyclic yoga 2 sessions per week for 12 weeks. Borg scale scores was gathered in all sessions and multiply to the duration of sessions to calculate the training load. A Rockport walk test and shoulder flexibility was taken to assess aerobic capacity and flexibility pre to and post training protocol respectively.
Blood samples were collected at baseline and post-intervention; then the lymphocytes were isolated and gene expression was analysis by real-time PCR technique. The REST software was used to analysis data.
The data showed p53 gene expression upregulated in the YHD group (exp: 4.03, p=0.001) and without change in the YLD group (exp:0.91, p=0.94) compared to the HD group (control group). The intervention did not change the NF-kB expression in any groups. The range of training load was between 720-840 units. There were significant improvements in Rockport test and shoulder flexibility in both experimental groups compared to HD group without any differences between experimental groups.
A combination of a high dose of vitamin D and yoga cause to increase the p53 expression, which is an important gene in inhibiting the recurrence of cancer. Improvement of aerobic capacity and shoulder flexibility with yoga indicating improving the life quality for doing routine tasks. Therefore, breast cancer survivors are recommended to perform yoga with a high dose of vitamin D.
Thirty female breast cancer survivors were randomized equally into three groups: high dose of vitamin D supplementation 4000 IU (HD), yoga with high dose of vitamin D 4000 IU (YHD), yoga with low dose of vitamin D 2000 IU(YLD). Experimental groups performed cyclic yoga 2 sessions per week for 12 weeks. Borg scale scores was gathered in all sessions and multiply to the duration of sessions to calculate the training load. A Rockport walk test and shoulder flexibility was taken to assess aerobic capacity and flexibility pre to and post training protocol respectively.
Blood samples were collected at baseline and post-intervention; then the lymphocytes were isolated and gene expression was analysis by real-time PCR technique. The REST software was used to analysis data.
The data showed p53 gene expression upregulated in the YHD group (exp: 4.03, p=0.001) and without change in the YLD group (exp:0.91, p=0.94) compared to the HD group (control group). The intervention did not change the NF-kB expression in any groups. The range of training load was between 720-840 units. There were significant improvements in Rockport test and shoulder flexibility in both experimental groups compared to HD group without any differences between experimental groups.
A combination of a high dose of vitamin D and yoga cause to increase the p53 expression, which is an important gene in inhibiting the recurrence of cancer. Improvement of aerobic capacity and shoulder flexibility with yoga indicating improving the life quality for doing routine tasks. Therefore, breast cancer survivors are recommended to perform yoga with a high dose of vitamin D.
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