A Randomized Controlled Trial of Immunomodulatory Effects of Exercise in Multiple Sclerosis Patients with Different Disability Levels

Oral Presentation
Paper ID : 1202-12THCONG
Oral / Poster Presentation File: 1202-12THCONG.mp4 
1Department of Sport Sciences, Shahrekord University, Shahrekord
2Department of Sport Sciences, Shahrekord University, Shahrekord, Iran.
Besides the physical benefits, exercise training triggers immunologic responses with an anti-inflammatory effect in multiple sclerosis patients. This study aimed to investigate the effect of a combined personalized exercise training program on resting level of inflammatory factors in female multiple sclerosis patients with different levels of disability.
In this randomized controlled trial Ninety-four women with MS were randomly assigned into exercise or control conditions with randomization stratified by Expanded Disability Status Scale (EDSS) scores of low (EDSS< 4.5), moderate (4.5 ≤EDSS≤ 6), or high (EDSS≥ 6.5) disability. The exercise program comprised resistance, endurance, Pilates, balance and stretch exercises; the control condition was assigned as waitlist control. Resting level of inflammatory factors, functional capacity, and lipid profile were evaluated before and after the intervention period. Two-way analysis of variance (condition×disability) was used for between-group comparisons.
Exercise training significantly improved hs-CRP, IFN-ƴ, IL-6 and PTX-3 but not Fibrin D-dimer (FDD) (p≤0.05). The effect of exercise was independent on disability status. Also, Exercise training significantly improved lipid profile (cholesterol, HDL, LDL and TG) and functional capacity (1RM, lat pull-down, knee extension and seated row, 6MWT and TUG) independent on disability status (p≤0.05).
It seam, exercise can stimulate anti-inflammatory effect consistent with improvements in lipid profile and functional capacity in women with MS, and this is generally not influenced by disability status. Exercise training may be an adjuvant for disease-modifying therapy among people with MS, and its effect may not be moderated by disability status.