Osteosarcopenic Obesity Markers Changes following Elastic Band Resistance Training in Osteosarcopenic Obese Women: a Randomized Controlled Trial

Oral Presentation
Paper ID : 1192-12THCONG
Oral / Poster Presentation File: 1192-12THCONG.mp4 
1Department of Sport Sciences, Faculty of Humanities, Shahrekord University, Shahrekord, Iran.
2Department of Sport Sciences, Faculty of Humanities, Shahrekord University, Shahrekord
Osteosarcopenic obesity (OSO) has been recently identified as a triad geriatric syndrome characterized by concurrent appearance of osteoporosis, sarcopenia, and fat redistribution in the abdominal region. The main purpose of present study was to investigate the effects of elastic band resistance training (EBRT) on OSO Z-score, muscle quality (MQ), procollagen III N-terminal peptide (P3NP), C-terminal agrin fragment (CAF), C-telopeptides of type I collagen (CTX-I), skeletal muscle-specific troponin T (sTnT), sclerostin, leptin, adiponectin, estradiol (E2) and physical performance in women living with OSO syndrome.
On the basis of the Consolidated Standards of Reporting Trials (CONSORT) Statement for randomized trials of non-pharmacologic treatments a total number of 75 women with OSO syndrome were recruited and assessed using a dual energy X-ray absorptiometry (DXA) instrument, body mass index (BMI)>30 kg/m2, -2.5≤T-score≤-1.0 of L1-L4, and/or total femur or femoral neck, and 10-meter walk test (10MWT) ≤1 m/s2 gait speed, and randomly divided in EBRT (n=38) or control condition (n=37). The 12-week supervised EBRT was designed to train all major muscle groups for 3 times per week. Two-way analysis of variance (time×group) was used for between-group comparisons. Also, Pearson's correlation was used for investigation of correlation between OSO markers and physical performance. Intention-to-treat (ITT) was further employed for data analysis.
After 12 weeks of intervention, serum E2 levels (p=0.006), MQ (p=0.043), OSO Z-score (p=0.030), 30-second (30s) chair-stand test (p=0.036), hand grip strength (p=0.013), and results of short physical performance battery (SPPB) (p=0.001) significantly increased and leptin (p=0.001) decreased in a significant manner in the experimental group compared with those in the controls. Also, MQ and hand grip was significantly correlated with all OSO markers and physical performance variables (p≤0.05), except for CAF.
Taken together, the results of this study showed that chronic EBRT in addition to complete safety, improve physical performance and OSO markers of osteosarcopenic obese women. In addition, MQ and hand grip can be expressed as available and routine diagnostic indices for OSO due to its association with other OSO markers and physical performance variables.