The effect progressive resistance training on the correlation between hippocampus weight and BDNF gene expression in diabetic rats
Poster Presentation
Paper ID : 1642-12THCONG
Authors
1M.Sc Student of Exercise physiology, Sport Science Department, Human Faculty, Semnan University, Semnan, Iran
2Assistant Professor of Exercise physiology, Sport Science Department, HumanFaculty, Semnan University, Semnan, Iran
3Assistant Professor of Exercise physiology, Sport Physiology Department, Physical education and Sport Sciences faculty, Kharazmi University, Tehran, Iran
Abstract
Exercise is a powerful driver for reducing the complications of diabetes. The aim of the present study was to investigate the effect of 6 weeks of progressive resistance training on the correlation between hippocampus weight and expression of brain-derived neurotrophic factor gene in the hippocampus in Wistar diabetic rats.
For this study, 36 rats weighing 160 ±10 g were randomly divided into 3 groups of 12 diabetic (D), diabetic and progressive resistance training (DRT) and control (C) groups. STZ solution (50 mg / kg) was used to induce diabetes. After a week of familiarization with the environment and practice, progressive resistance training protocol 3 days a week, each session consisting of 4 to 9 sets of 110cm vertical ladders with 2cm stairs and 85 ° angles of 50%, 75%, 90% and It was 100% maximum load capacity. Animals were dissected 48 hours after training. Hippocampus was extracted and weighed and BDNF gene expression was evaluated using Real Time PCR technique.
The results showed a high correlation ( Correlation= 0/91839) between hippocampal weight and BDNF gene expression in male Wistar diabetic rats as a result of progressive resistance training
progressive resistance training can prevent hippocampal tissue analysis due to diabetes, and is important in diabetic patients because of the positive role of the hippocampus on memory. Also, progressive resistance training are effective in maintaining the physical fitness of diabetics Therefore, progressive resistance training is recommended to improve the physical health and lift of diabetic patients.
For this study, 36 rats weighing 160 ±10 g were randomly divided into 3 groups of 12 diabetic (D), diabetic and progressive resistance training (DRT) and control (C) groups. STZ solution (50 mg / kg) was used to induce diabetes. After a week of familiarization with the environment and practice, progressive resistance training protocol 3 days a week, each session consisting of 4 to 9 sets of 110cm vertical ladders with 2cm stairs and 85 ° angles of 50%, 75%, 90% and It was 100% maximum load capacity. Animals were dissected 48 hours after training. Hippocampus was extracted and weighed and BDNF gene expression was evaluated using Real Time PCR technique.
The results showed a high correlation ( Correlation= 0/91839) between hippocampal weight and BDNF gene expression in male Wistar diabetic rats as a result of progressive resistance training
progressive resistance training can prevent hippocampal tissue analysis due to diabetes, and is important in diabetic patients because of the positive role of the hippocampus on memory. Also, progressive resistance training are effective in maintaining the physical fitness of diabetics Therefore, progressive resistance training is recommended to improve the physical health and lift of diabetic patients.
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