Are there any differences between the effect of Resistance and endurance training on spatial learning and memory in the rat model of AD?
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Paper ID : 1517-12THCONG
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Depatment of physical education and sports scinces, Marand branch,Islamic azad university, Marand,Iran
The global prevalence of dementia such as Alzheimer's disease (AD) is increasing substantially, yet an effective treatment has not yet been found. Physical activity, especially aerobic exercise, has a protective effect on cognitive function and memory in the elderly and Alzheimer's patients. Recent research suggests resistance training may also have a positive effect on memory and brain function, however, it is unclear which type of training is more effective. The aim of this study was to compare the effects of resistance (using vertical ladder apparatus, three times a week by the connection of weights to the tail, 10 set with 30 s rest, for 8 weeks) and endurance exercise training (using animal treadmill, three times a week, 40 min with 20 m/min, for 8 weeks) on spatial learning and memory in rat model of AD induced by i.c.v. osmotic pump infusion of β-Amyloid25-35 peptides. Spatial memory and learning were evaluated by the Morris water maze test. Thirty-six animals were divided into six groups: (1) animals without any intervention (control); (2) animals with endurance training (treadmill); (3) animals with resistance training (Resistance); (4) animals with Aβ25-35 injection without any training (Aβ+normal saline); (5) animals with Aβ25-35 injection with endurance training (Aβ+treadmill); and (6) animals with Aβ25-35injection with resistance training (Aβ+Resistance). The results showed that Aβ+Resistance and Aβ+treadmill groups have significantly less escape latency time to reach the hidden platform and more spent time in the target quadrant compared to Aβ+normal saline group (P<0.005). However, Post hoc analysis did not reveal any significant differences in values between the two groups (P<0.005). Finally, we conclude that resistance training and endurance training could equally improve spatial learning and memory in AD animals and may subsequently prevent the progress of memory disease.