Increase of Anti-Apoptotic Factors in Non-Active Obese Men: Exercise and Glucose Tolerance
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Paper ID : 1456-12THCONG
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1MSc in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education, University of Urmia, Urmia, Iran.
2Professor of Biochemistry, Urmia University of Medical Sciences
3Assistant Professor of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
Studies proved that Irisin and Krüppel-like factors15 have anti-apoptotic role on pancreatic beta-cells and stimulates beta-cell proliferation, insulin biosynthesis and secretion.

The aim of the present study was to the effect of eight weeks aerobic exercise training on Krüppel-like factors 15, Irisin and Insulin resistance in non-active obese men.
This semi experimental study was performed with pre-test and post- test designed with a training group and a control group. Twenty obese middle-aged men in the age range of 30-45 years old participated in this study. They were randomly divided into two groups. Aerobic exercise group (n = 10) and control group (n = 10). Exercise group performed eight weeks (3 sessions a week, from 50% maximum heart rate progressed gradually to 80% - 15 to 45 minutes) aerobic trainings. Blood samples were taken 24 hours before and 48 hours after training period. Data were analyzed by t-test and ANOVA at the significance level (p≤ 0.05).
The results showed that after eight weeks aerobic exercise training, Krüppel-like factors 15 (p = 0.006) and Irisin (p = 0.001) have a significant increase and Insulin resistance (p= 0.009) had a significant decrease compared to pre-test and control group.
Eight weeks aerobic exercise training caused to increase in Krüppel-like factors 15 and Irisin. These changes have a significant correlation with lowered Insulin resistance. So, these changes can improve glucose tolerance and reduce Insulin resistance, which can initiate a novel strategy for the treatment of obesity and diabetes.