The Response of Adipokine Serum Levels to Resistance Exercise: Improving Insulin Actions by Suppressing the Gluconeogenesis in the Liver
Poster Presentation XML
1MSc in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education, University of Urmia, Urmia, Iran.
2Assistant Professor of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
3Department of Exercise Physiology and Corrective Movement, Faculty of Physical Education and Sport Sciences, Urmia University, Urmia
Adipolin has insulin-sensitizing actions by suppressing gluconeogenesis and promoting glucose uptake in hepatocytes. Overexpression of FST in the pancreas preserves β-cell function by promoting β-cell proliferation, opening up a new therapeutic avenue for the treatment of diabetes. Exercise health benefits are partly mediated by exertional changes in several myokines/adipokines. Adipolin and Follistatin suppress glucose output in hepatocytes. They improve insulin actions by suppressing the gluconeogenesis and improving glucose uptake of hepatocytes also lower blood glucose and reduce serum insulin levels in conditions of obesity.

The purpose of the present study was to investigate 8 weeks resistance training on plasma Adipolin, Insulin resistance, and Follistatin in obese men.
In this study, 20 obese middle-aged man in the age range of 45-30 years old randomly divided into two groups including one groups of resistance training (n=10) and one control group (n=10) . Resistance training group, 3 sessions per week and for 8 weeks, went on to work (3 sets with 10 repetitions, 30-70% 1RM). 48 hours after the end of the training session, a blood sample was taken and the levels of adipolin, insulin and plasma follistatin were measured. The findings analysed by independent t-test and ANOVA in SPSS-22 software.
Data analysis indicated that plasma level of follistatin in the training group were significantly higher than the control group (p= 0.015). Insulin resistance index decreased not significantly in exercise group compared to control group (p= 0.306). Adipolin in the training group was not significantly increased than the control group (p= 0.238).
8 weeks resistance training by increasing plasma level of follistatin from β-cell can improve insulin actions by suppressing the gluconeogenesis and improving glucose uptake of hepatocytes.