The effect of Physical activity intervention on quality of life of patients with breast cancer: A systematic review and meta-analysis of Randomized Controlled Trials

Poster Presentation
Paper ID : 1453-12THCONG
Oral / Poster Presentation File: Nazanin_Goudarzi_Meta Analysis.JPG 
1Integrative oncology and quality of life department, breast cancer research center, Motamed Cancer Institute, Tehran, Iran
2Integrative oncology and quality of life department breast cancer research center moted cancer institute
3Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Integrative Oncology and Quality of life department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
Quality of life of patients with breast cancer is affected by different criteria of life style modification including physical activity intervention.
The aim of this systematic review and meta-analysis was to determine the effect of physical activity intervention on quality of life (QOL) in patients with breast cancer and breast cancer survivors.
We searched PubMed, Scopus, ISI Web of Science, Cochrane, central register for controlled trials database until September 2019 for relevant controlled trials. Mean differences and standard deviations of QOL, were pooled using a random-effects model. Effect size data was extracted using Comprehensive Meta-analysis V2. Quality of evidence was evaluated using Cochrane Collaboration Risk of Bias tool and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Thirty-nine trials (n=4196 participants) were included in this meta-analysis.
We observed that physical activity had a significant increasing effect on QOL (39 trials, n=4196, weighted mean difference (WMD) = 0.539; 95%CI: 0.319, 0.758; P = 0.000; I2 = 91.3 %; P-heterogeneity=0.000). Sub-group analysis showed that, a physical activity intervention of 18 to 24 weeks was found to have a rising effect on QOL measures in patients with breast cancer (9 trials, n=765 participants, WMD= 0.216; 95%CI: 0.069, 0.363; P = 0.004; I2 = 4.8%; P-heterogeneity=0.395). Besides, physical activity intervention had a significant elevating effect on QOL of patients with breast cancer in the studies of which QOL was assessed using FACT-An questionnaire (7 trials, n=1036 participants, WMD= 0.176; 95%CI: 0.053, 0.299; P = 0.005; I2 = 0.0%; P-heterogeneity=0.944). Other sources of heterogeneity were found to be home-based exercise intervention, a group of participants including the patients who were under chemotherapy treatment and the patients who were completed with their chemotherapy treatment, and the stage of 0 to 4 in the patients with breast cancer.
Although our data suggests that physical activity intervention had a significant improvement in QOL in patients with breast cancer, more studies with high-quality, large-scale, long-term duration and precise baseline characteristics are needed to assess the exact effective type, duration and efficacy of physical activity on QOL of the patients.