The effect of intense intermittent training and Ginkgo biloba plant on serum neurotrophic factors levels and cognitive Performance of Brain in Wistar Male Rats
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Authors
1Full Professor, Department of Sport Sciences, University of Birjaand
2MSc in Exercise Physiology, Sport Sciences Department, Faculty of Sport Sciences, University of Birjand, Birjand, Iran.
3Assistance Professor, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Abstract
The present study was conducted to investigate the effect of intense intermittent exercise and Ginkgo biloba on the serum levels of brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) and also learning in young rats.
The present study was an experimental research. Forty- two eight-week-old rats were randomly divided into six groups including control, low dose of Ginkgo biloba (65 mg/kg), high dose of Ginkgo biloba (100 mg/kg), exercise, exercise + low dose of Ginkgo biloba, exercise + high dose of Ginkgo biloba. The exercise protocol or Ginkgo biloba administration was six days a week for six weeks. The serum levels of BDNF and NT-4 were measured by ELISA method, and learning was evaluated by Morris water maze test in all groups. Data were analyzed using SPSS software and it is applied one -way ANOVA test for extracting of results.
Increased serum NT-4 levels following intense intermittent exercise, No change in serum BDNF, Increased serum BDNF following high doses of ginkgo biloba (P <0.05), Disorder in learning following the use of low dose of Ginkgobiloba in third day and low dose+ exercise in second day, Increased learning on the third day following the exercise, No changes in serum neurotrophin levels were observed in the combination of ginkgo biloba and exercises.
Consumption of Ginkgo biloba increased the serum BDNF level independent of the dose and exercise improved NT-4 serum, therefore, the use of ginkgo biloba at various doses with exercise is likely to help cognitive improvement in the brain of the rat.
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