The effect of 8 weeks moderate endurance training on P107 protein conten in type 2 diabetic male mice

Oral Presentation
Paper ID : 1422-12THCONG
Oral / Poster Presentation File: 1422-12THCONG. slides.pptx  1422-12THCONG. 1.mp4 
1MS.c in Exercise Physiology, Department of physical education, Taft Azad university,Taft, Iran
2Assistant Professor in Exercise Physiology, Department of physical education, Yazd university,Yazd, Iran
3Assistant Professor in Exercise Physiology, Faculty of sport science, Ferdowsi university of Mashhad, Mashhad, Iran
4PhD in Exercise Physiology, Department of physical education, Yazd university, Yazd, Iran
Recent studies have shown that P107 protein acts as a suppressor of transcription of PGC1α protein which is the main protein in the biogenesis and mitochondrial function. The main purpose of the study was to investigate the effect of 8 weeks of moderate endurance training on the levels of P107 protein and fasting blood glucose in type 2 diabetic mice.

21 male mice were randomly divided into 3 groups of healthy control(HC), diabetic control(DC) and diabetic training(DTG). DC and DTG groups were diabetic by intraperitoneal injection of streptozotocin and four weeks of free access to water and high-fat diets(%60).DTG group carried out 8 weeks of moderate endurance exercise that including running on treadmill for 3 sessions per week and 60 min per session with 5 m/min speed. 48 hours after the end of the training period, all mice were sacrificed in order to measure the levels ofP107 protein of gastrocnemius muscle and fasting blood glucose. ANOVA with Tukey and Bonferron's post hoc tests were used to determine the mean differences among the groups.

Results showed thatP107 protein content in DC group was significantly higher than the HC group(P<0/05). Also, this protein was significantly decreased in the DTG group compared to the DC group, but there was no significant difference between DTG and HC control groups. In conclusion,

moderate endurance training reduces P107 protein content in type 2 diabetic male mice, which indirectly restores at least part of mitochondrial function by reducing the suppression of PGC1α protein and, consequently, reduce the complications of type 2 diabetes.