The effect of 8 week aerobic exercise on ICAM-1, VCAM-1 and Hs-CRP in middle aged heart failure men
Poster Presentation XML
Paper ID : 1399-12THCONG
Oral / Poster Presentation File:
1Faculty Member of Sanabad Golbahar Institute of Higher Education
2Hakim Nezami Institute of Higher Education, Ghuchan, Iran
3Semnan sport medicine board
The evidence have shown expansion of cardiovascular disease have inflammation base and general inflammation (systemic) plays a pivotal role in the development of atherosclerosis. Some inflammatory factors can cause cardiovascular disease. Factors such as adhesion molecule and CRP (adhesion molecule–1, vascular adhesion molecule-1 and C–reactive protein). The purpose of this research was evaluation of changes in Inter cellular adhesion molecule–1, vascular adhesion molecule-1 and C–reactive protein in middle-aged men with heart failure after eight weeks of aerobic exercise.
Twenty four middle-aged men with heart failure with mean age of 58.16±5.24 years were selected as volunteers, and were divided into two groups; aerobic training group and control group. Aerobic training program was eight weeks, three sessions per week with an intensity of 40%-70% maximum heart rate. The control group had no activity for eight weeks and they were actually doing daily activities. Fasting blood samples before and after eight weeks were taken from all subjects. Data were analyzed by dependent student t-test and independent student t-test at a significance levels of P<0.05.
In the aerobic exercise group serum levels of ICAM-1, VCAM-1 and CRP (respectively P=0.001, P=0.001 and P=0.001) were significantly reduced. The comparison of between groups just VCAM-1 (P=0.001) and CRP (P=0.002) were significant.
The results of this study showed that, Aerobic exercise with reduced levels of inflammatory markers ICAM-1 and CRP may play a role in the prevention and control of cardiovascular disease in middle-aged men with heart failure. Therefore, aerobic activity can be suggested to prevent some cardiovascular diseases.