Endurance Training and Response of KLF15 and FST, as Promoting Markers of Adipocyte Browning

Poster Presentation
Paper ID : 1231-12THCONG
Oral / Poster Presentation File: Slide1.JPG 
1MSc in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education, University of Urmia, Urmia, Iran.
2Assistant Professor of exercise physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
3Department of Exercise Physiology and Corrective Movement, Faculty of Physical Education and Sport Sciences, Urmia University, Urmia
Brown adipose tissue (BAT) play an important role in thermogenesis in mammals that can improve insulin sensitivity and decrease body weight in humans. Follistatin (FST) and Krüppel-like factor 15 (KLF15) can by promoting the expression of some proteins potentially induce the browning of white adipose tissue (WAT). Thus, the browning of WAT is promoted by FST and KLF15.
The aim of this study was to investigate effect of endurance training on KLF15, FST on promote BAT.
In this study, 20 obese men (Age: 34.8 ± 3.58 years) were randomly assigned into control (n = 10) and training (n = 10) groups. Training groups performed 8 weeks (3 sessions a week, 50% maximum heart rate progressed gradually to 80%- 15 minutes to 45 minutes). Blood samples were taken 24 hours before and 48 hours after the intervention in fasting state. Data were analyzed by t-test and ANOVA at the significance level (p≤ 0.05).
After eight weeks, the results showed that KLF15 (p = 0.006) and FST (p = 0.001), had a significant increase and insulin resistance (p = 0.009), fat percentage (P = 0.001) and weight (P = 0.001) significantly decreased.
This study demonstrated that after 8 weeks, KLF15 and FST levels increased; in contrast, insulin resistance, fat percentage and weight levels decreased. So endurance training had beneficial effects on FST and KLF15 that can say great potential in the treatment of obesity and metabolic syndrome by inducing the browning of white fat and promoting glucose and lipid metabolism.