The effect of aerobic and combined training on changes in angiogenesis stimulating and inhibitory factor levels in healthy elderly men
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Paper ID : 1050-12THCONG
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Department of Sport Sciences, Faculty of Literature and Humanities, University of Qom, Qom, Iran
As the tissues and vessels age, they grow old and disturb the structure of the vascular network of tissues. Physical activity can affect body function and prevent many problems during this period.

in the present study, we investigated the effect of 8 weeks of aerobic and combined
training on angiogenesis factors TGF-β1 and TIMP-1 in healthy elderly men.

In this semi-experimental study, 30 healthy elderly men with the mean age of 50-60 years were selected and randomly assigned into 3 groups of aerobic exercise, combined exercise and control group. The exercise sessions were held 3 days a week for 8 consecutive weeks. Aerobic training consisted of running on the track with an intensity of 60-75% of maximal heart rate reserve. Combined exercises (aerobic - resistance) consisted of running at the same percentage of maximum heart rate and resistance trainings consisted of 5 movements with 60% 1RM intensity which had reached to 75% of 1RM during the training weeks. The shuttle run protocol was used to estimate the maximum oxygen consumption. Blood samples used for measurement were collected 24 hours before the first and 48 hours after the last session in fasting condition. ANOVA and T test were used to compare inner and inter group averages at the significant level of P≤0.05.

compared to the control group, the results of the present study showed significant changes in TGF-β1 level (P = 0.015) and TIMP-1 (P = 0.001) in training groups because of aerobic and combined trainings. Based on post-test measures, TGF-B1 has increased in combined ( P = 0.001) and aerobic ( P = 0.006) groups and TIMP-1 has decreased significantly in combined and aerobic group
( P = 0.001) compared to pre-test results.
It seems that exercise activities can cause the increase of the angiogenesis factor TGF-B1 and the positive decrease of TIMP-1, and physical activities may be used as an approach to prevent the problems related to age.